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The American Journal of Psychiatry, VOL. 132, No. 9

REGULAR ARTICLES | September 01, 1975

Steady-state protriptyline levels in an outpatient population

Am J Psychiatry 1975;132:960-962.

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Abstract

The authors measured steady-state protriptylive levels in 12 outpatients undergoing treatment for depression. The steady-state level of protriptyline was surprisingly high compared with levels obtained when other tricyclic antidepressants were prescribed. This finding probably accounts for the effectiveness of protriptyline at low doses and its frequent side effects.

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