When a patient capable of articulate reporting was prepared with deep and surface electrodes, correlations were demonstrated between activity at certain brain sites and pleasurable or painful affect. Moreover, a functional relationship was shown between these sites for emotional expression and some sensory relay nuclei. These findings substantiate previous observations made in the Tulane University depth electrode series and add meaning to anatomic and physiologic data from animal studies that have shown an integral relationship between brain sites involved in sensory perception and those for emotional expression.Abstract Teaser