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The American Journal of Psychiatry, VOL. 131, No. 7

Articles | July 01, 1974

The Antagonism of Amphetamine-Induced Symptomatology by a Neuroleptic

B. ANGRIST; H. K. LEE; S. GERSHON

Am J Psychiatry 1974;131:817-819.

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Director, Mental Health Clinic, Bronx-Lebanon Hospital Center, Bronx, N.Y.

Professor, Mental Health Clinic, Bronx-Lebanon Hospital Center, Bronx, N.Y.

1974, The American Psychiatric Association

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Abstract

A neuroleptic (haloperidol) that, in the doses used, is a specific blocker of dopamine was effective in antagonizing amphetamine-induced symptoms in eight patients. This finding suggests that dopaminergic mechanisms play an important role in amphetamine psychosis, as well as the additional possibility that these mechanisms may be important in other psychotic states.

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