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The American Journal of Psychiatry, VOL. 131, No. 1

Articles | January 01, 1974

Methyltestosterone with Imipramine in Men: Conversion of Depression to Paranoid Reaction

IAN C. WILSON; ARTHUR J. PRANGE; PATRICIO P. LARA

Am J Psychiatry 1974;131:21-24.

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Research Psychiatrist, Dorothea Dix Hospital, Raleigh, N.C. 27611

University of North Carolina, Chapel Hill and Professor of Psychiatry and Director of Research Development, Department of Psychiatry and Biological Sciences Research Center

Research Fellow, Department of Psychiatry and University of North Carolina, Chapel Hill

1974, The American Psychiatric Association

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Abstract

Five men with primary unipolar depression were treated with methyltestosterone and imipramine. Four promptly showed a paranoid response that cleared rapidly when treatment with the hormone was discontinued. The shift from depression to a paranoid reaction may have resulted from an increase in aggression, which may in turn have been the result of the interplay between the hormone and the drug and the effects of this interplay on brain biogenic amine metabolism.

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