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The American Journal of Psychiatry, VOL. 131, No. 2

Articles | February 01, 1974

Lithium Prophylaxis in Recurrent Affective Illness

ROBERT F. PRIEN; C. JAMES KLETT; EUGENE M. CAFFEY

Am J Psychiatry 1974;131:198-203.

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Research Psychologist, at the Central Neuropsychiatric Research Laboratory, Veterans Administration Hospital, Perry Point, Md. 21902

Chief at the Central Neuropsychiatric Research Laboratory, Veterans Administration Hospital, Perry Point, Md. 21902

Deputy Director, Mental Health and Behavioral Sciences Service, Department of Medicine and Surgery, Veterans Administration, Washington, D.C.

1974, The American Psychiatric Association

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Abstract

The authors report on two recent two-year studies that attempted to determine the effectiveness of lithium carbonate in treating recurrent affective illness. In study I, 205 bipolar (manic-depressive) patients were randomly assigned to lithium or placebo; in study 2, 44 bipolar and 78 unipolar (depressive) patients were randomly assigned lithium, imipramine, or placebo. The results showed lithium to be effective in treating both manic and depressive episodes and imipramine to be effective in treating depressive episodes. The findings emphasize the importance of considering the patient's previous course of illness in selecting a program of maintenance treatment.

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