The authors conducted a post hoc comparison of two very similar doxepin studies that included outpatients with mixed anxiety and depression. The first study used a three-times-a-day schedule, and the second used a bedtime schedule. All differences between the two treatments favored the bedtime regimen. Although the reports cannot take the place of a direct comparison between the two dosage schedules, they offer evidence for the usefulness and value of single-dose bedtime medication for anxious-depressed outpatients receiving doxepin treatment.Abstract Teaser