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The American Journal of Psychiatry, VOL. 130, No. 1

Articles | January 01, 1973

L-Dopa, Dopamine, and Hypomania

DENNIS L. MURPHY; FREDERICK K. GOODWIN; H. KEITH H. BRODIE; WILLIAM E. BUNNEY

Am J Psychiatry 1973;130:79-82.

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Clinical Research Unit Chief, Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md.

Assistant Professor of Psychiatry, Stanford University Medical School, Stanford, Calif.

Director, Division of Narcotics and Drug Abuse, NIMH

1973, The American Psychiatric Association

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Abstract

Greater urinary excretion of dopamine during L-dopa administration was observed in bipolar than in unipolar depressed patients. The authors suggest that increased levels of brain dopamine may play a role in the development of hypomania and mania, since there is a tendency for bipolar patients to regularly develop hypomanic episodes during L-dopa treatment and since evidence from animal studies indicates that increased brain dopamine is highly correlated with increased psychomotor activity.

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