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The American Journal of Psychiatry, VOL. 130, No. 7

Articles | July 01, 1973

A Dimethyltryptamine-Forming Enzyme in Human Blood

RICHARD J. WYATT; JUAN M. SAAVEDRA; JULIUS AXELROD

Am J Psychiatry 1973;130:754-760.

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Acting Chief, Laboratory of Clinical Psychopharmacology, Saint Elizabeths Hospital, Washington, D.C. 20032, National Institute of Mental Health

NIH International Postdoctoral Fellow, National Institute of Mental Health

Chief of the Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health

1973, The American Psychiatric Association

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Abstract

An enzyme capable of forming the hallucinogen dimethyltryptamine was found in human red blood cells, plasma, and platelets. The enzyme activity in red blood cells and plasma was not significantly different in psychiatric patients from that in normal subjects. The enzyme activity in platelets was higher in psychotic subjects than in nonpsychotics and was apparently related to the presence of a dialyzable inhibitor in the normal subjects.

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