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The American Journal of Psychiatry, VOL. 130, No. 1

Articles | January 01, 1973

Cerebrospinal Fluid Amine Metabolites in Affective Illness: The Probenecid Technique

FREDERICK K. GOODWIN; ROBERT M. POST; DAVID L. DUNNER; EDNA K. GORDON

Am J Psychiatry 1973;130:73-79.

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Principal Research Scientist, New York State Psychiatric Institute, New York, N.Y.

1973, The American Psychiatric Association

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Abstract

Probenecid inhibits the removal of 5-HIAA and HVA (the major metabolites of serotonin and dopamine) from the cerebrospinal fluid. The accumulation of these metabolites following high doses of probenecid was studied in patients with affective illness in order to assess central amine function. The metabolite accumulation was increased by administering the appropriate precursors (which increase amine synthesis) and was decreased by administering specific synthesis inhibitors. Compared with controls, the depressed patients had low HVA accumulation, while addicts on methadone had low 5-HIAA accumulation. Within the group of depressed patients, HVA accumulation was higher in bipolar than in unipolar patients.

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