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The American Journal of Psychiatry, VOL. 130, No. 1

Articles | January 01, 1973

Amphetamine Psychosis: A "Model" Schizophrenia Mediated by Catecholamines

SOLOMON H. SNYDER

Am J Psychiatry 1973;130:61-67.

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Professor of Psychiatry and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Md. 21205

1973, The American Psychiatric Association

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Abstract

Because of its close clinical similarity to acute paranoid schizophrenia, amphetamine psychosis may serve as a useful experimental model for schizophrenia. Molecular and clinical studies suggest that both the schizophrenia-like symptoms of amphetamine psychosis and the specific ability of phenothiazines to relieve the symptoms of schizophrenia and amphetamine psychosis may be the result of interactions with dopamine systems in the brain. The author discusses some implications of the roles dopamine and norepinephrine may play in mediating some schizophrenic symptoms.

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