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The American Journal of Psychiatry, VOL. 130, No. 12

Articles | December 01, 1973

Plasma Binding of Imipramine and Clinical Outcome

ALEXANDER H. GLASSMAN; MARIA J. HURWIC; JAMES M. PEREL

Am J Psychiatry 1973;130:1367-1369.

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Acting Director, Department of Biological Psychiatry, New York State Psychiatric Institute, 722 West 168th St., New York. N.Y. 10032

Senior Research Scientist, Department of Biological Psychiatry, New York State Psychiatric Institute, 722 West 168th St., New York. N.Y. 10032

Associate Research Scientist and Laboratory Chief, Department of Biological Psychiatry, New York State Psychiatric Institute, 722 West 168th St., New York. N.Y. 10032

1973, The American Psychiatric Association

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Abstract

The binding of imipramine to plasma protein was examined in 26 depressed patients. In contrast to the findings of previously published reports, the fraction of the drug that remained unbound was found to vary significantly from one patient to another. This finding provides a possible explanation for the discrepancies that have been found in studies that have attempted to correlate plasma levels of antidepressant drugs and clinical outcome.

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