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The American Journal of Psychiatry, VOL. 130, No. 12

Articles | December 01, 1973

Manic-Depressive Illness: Linkage with the Xg Blood Group

RONALD R. FIEVE; JULIEN MENDLEWICZ; JOSEPH L. FLEISS

Am J Psychiatry 1973;130:1355-1359.

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Chief of Psychiatric Research, Department of Internal Medicine, and Director of the Lithium Clinic, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Professor of Clinical Psychiatry, Columbia University

Visiting Psychiatrist, Department of Medical Genetics, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Research Associate in Psychiatry, Columbia University

Research Scientist, Department of Biometrics, New York State Department of Mental Hygiene, New York, N.Y. and Associate Professor of Biostatistics, Columbia University

1973, The American Psychiatric Association

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Abstract

Manic-depressive illness and the Xg blood group, a genetic marker located on the X chromosome, showed measurable linkage in successive generations of six families. These data suggest that a dominant X-linked factor is involved in the transmission of manic-depressive illness within the families studied.

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