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The American Journal of Psychiatry, VOL. 130, No. 10

Articles | October 01, 1973

Single Versus Divided Daily Dose of Trimipramine in the Treatment of Depressive Illness

M. Z. HUSSAIN; Z. A. CHAUDHRY

Am J Psychiatry 1973;130:1142-1144.

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Senior Psychiatrist, Psychiatric Centre, Victoria Union Hospital, 1200-24th St. West, Prince Albert, Sask., Canada

Resident in psychiatry, Psychiatric Centre, Victoria Union Hospital, 1200-24th St. West, Prince Albert, Sask., Canada

1973, The American Psychiatric Association

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Abstract

A group of 56 patients with depressive illnesses were administered either a single daily dose or a divided daily dose of trimipramine on a random basis. Results of the treatment showed several advantages for the use of a single daily dose: a trend toward better therapeutic improvement, a significant decrease in the side effects of insomnia and fatigue, and more regular consumption of the medication.

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