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The American Journal of Psychiatry, VOL. 130, No. 10

Articles | October 01, 1973

Evolving Behavior in the Clinical and Experimental Amphetamine (Model) Psychosis

EVERETT H. ELLINWOOD; ABRAHAM SUDILOVSKY; LINDA M. NELSON

Am J Psychiatry 1973;130:1088-1093.

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Director and Professor of Psychiatry, Behavioral Neuropharmacology Section, Department of Psychiatry, Duke University Medical Center, Durham, N.C. 27710

Research Associate, Behavioral Neuropharmacology Section, Department of Psychiatry, Duke University Medical Center, Durham, N.C. 27710

Senior Research Technician, Behavioral Neuropharmacology Section, Department of Psychiatry, Duke University Medical Center, Durham, N.C. 27710

1973, The American Psychiatric Association

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Abstract

A parallel is drawn between several behavioral constellations observed in the evolution of the human amphetamine psychosis and the motor-postural-attitudinal manifestations induced in animals by chronic amphetamine intoxication. On the basis of the results reported, a triple-layered model of psychosis is suggested and the roles played by participating neurotransmitters and mechanisms are further elaborated.

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