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The American Journal of Psychiatry, VOL. 130, No. 9

Articles | September 01, 1973

The Treatment of Depression with a Single Daily Dose of Imipramine Pamoate

J. MENDELS; JOSEPH DIGIACOMO

Am J Psychiatry 1973;130:1022-1024.

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Professor and Chief, Depression Research Unit, University of Pennsylvania, Philadelphia, Pa. and Philadelphia Veterans Administration Hospital, University and Woodland Aves., Philadelphia, Pa. 19104

Associate Professor, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa. and Philadelphia Veterans Administration Hospital, University and Woodland Aves., Philadelphia, Pa. 1910

1973, the American Psychiatric Association

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Abstract

A controlled comparison of the effects of 50 mg. of imipramine hydrochloride given three times daily and 150 mg. of imipramine pamoate in a single bedtime dose revealed no significant difference in either therapeutic effects or side effects in a group of 40 hospitalized depressed patients. The authors note the advantages of a single night dose of antidepressant medication.

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