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The American Journal of Psychiatry, VOL. 130, No. 9

Articles | September 01, 1973

Relationship Between the Effectiveness of Lithium Therapy and Family History

JULIEN MENDLEWICZ; RONALD R. FIEVE; FRANK STALLONE

Am J Psychiatry 1973;130:1011-1013.

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New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Visiting Research Fellow, Belgian American Education Foundation, Department of Medical Genetics and Senior Psychiatrist, Brugmann Psychiatric Hospital, Brussels, Belgium

New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Chief of Psychiatric Research, Department of Internal Medicine and Metabolic Research Unit and Professor of Clinical Psychiatry, Columbia University College of Physicians and Surgeons, New York. N.Y.

New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Associate Research Scientist

1973, the American Psychiatric Association

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Abstract

As part of a continuing study, 72 manic-depressive patients were randomly assigned to treatment with either lithium carbonate or placebo. Of these, 67 percent were treated successfully and 33 percent were long-term failures. Data that reflected the incidence of psychopathology in the first- and second-degree relatives of the patients were collected. Striking differences were observed in the backgrounds of lithium responders and failures: response to lithium treatment was significantly associated with the presence of manic-depressive illness in the patients' families.

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