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The American Journal of Psychiatry, VOL. 130, No. 1

Articles | January 01, 1973

Usual and Unusual Agranulocytosis During Neuroleptic Therapy

J. V. ANANTH; J. V. VALLES; J. P. WHITELAW

Am J Psychiatry 1973;130:100-102.

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Director of Education, Division of Psychopharmacology, and Assistant Professor, Department of Psychiatry, Douglas Hospital, McGill University, Montreal, Que., Canada and Chief, Research Unit, Department of Psychiatry, St. Mary's Hospital, Montreal

Resident in psychiatry, Douglas Hospital, McGill University, Montreal, Que., Canada

Intern in psychiatry, Douglas Hospital, McGill University, Montreal, Que., Canada

1973, The American Psychiatric Association

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Abstract

Agranulocytosis, an uncommon side effect of phenothiazine treatment, usually occurs within the first three months of such treatment and remits after the substitution of another neuroleptic. The authors report one patient in whom the illness took its usual course and two in whom it did not. Of these two, one patient demonstrated agranulocytosis only after years of phenothiazine therapy and the other showed agranulocytic reactions to various neuroleptics.

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