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The American Journal of Psychiatry, VOL. 129, No. 1

Articles | July 01, 1972

The Use of Doxepin in the Treatment of Symptoms of Anxiety Neurosis and Accompanying Depression: A Collaborative Controlled Study

HAROLD L. GOLDBERG; RICHARD J. FINNERTY

Am J Psychiatry 1972;129:74-77.

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Director of West-Ros-Park Mental Health Center, Boston State Hospital and Assistant Clinical Professor of Psychiatry at Boston University School of Medicine

Psychopharmacology Research Group, Boston State Hospital and Research Fellow at Tufts University Medical School

1972, American Psychiatric Association

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Abstract

Fifty-two outpatients with the main target symptom of anxiety with accompanying depression were randomly assigned to receive either doxepin or placebo in a double-blind study for four weeks. The doxepin group improved significantly on global ratings at one week and at four weeks. It was found that at one week patients were significantly improved on symptoms of anxiety, while at four weeks significant improvement occurred in depressive symptomatology.

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