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The American Journal of Psychiatry, VOL. 128, No. 4

Articles | October 01, 1971

The Safety of a Single Daily Dose Schedule for Imipramine

KISHORE SARAF; DONALD F. KLEIN

Am J Psychiatry 1971;128:483-484.

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Resident in Psychiatry, Research Department, Hillside Hospital, 75-59 263rd St., Glen Oaks, N.Y. 11004

Director of Research, Hillside Hospital, 75-59 263rd St., Glen Oaks, N.Y. 11004

1972, American Psychiatric Association

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Abstract

One reason for the traditional administration of medication in divided doses is that this is assumed to be safer than administration in single doses. The authors' analysis of clinical and laboratory data from 43 adult patients supports the view that imipramine hydrochloride may safely be given in a single nightly dose.

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