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The American Journal of Psychiatry, VOL. 128, No. 11

Articles | May 01, 1972

Effects of Imipramine and Dextroamphetamine on Behavior of Neuropsychiatrically Impaired Children

BERTRAND G. WINSBERG; IRV BIALER; SAMUEL KUPIETZ; JACK TOBIAS

Am J Psychiatry 1972;128:1425-1431.

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Research Medical Director, Child Psychiatric Evaluation Research Unit, New York State Department of Mental Hygiene, 524 Clarkson Ave., Brooklyn, N.Y. 11203

Principal Research Scientist, Child Psychiatric Evaluation Research Unit, New York State Department of Mental Hygiene, 524 Clarkson Ave., Brooklyn, N.Y. 11203

Senior Research Scientist, Child Psychiatric Evaluation Research Unit, New York State Department of Mental Hygiene, 524 Clarkson Ave., Brooklyn, N.Y. 11203

Associate Professor, Department of Child Psychiatry, Downstate Medical Center, Brooklyn, N.Y.

1972, American Psychiatric Association

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Abstract

This study assessed the comparative effectiveness of imipramine, placebo, and dextroamphetamine as therapeutic agents for the control of hyperkinetic and aggressive behaviors in children. Behavioral change under the drug conditions was evaluated using a 39-item behavior rating scale. The results indicate that imipramine is an effective agent for the control of hyperactivity and aggression in behaviorally impaired children. Implications of the findings for clinical application in pediatric psychopharmacology are presented and discussed.

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