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The American Journal of Psychiatry, VOL. 128, No. 11

Articles | May 01, 1972

Physiological Studies of the Hyperkinetic Child: I

JAMES H. SATTERFIELD; DENNIS P. CANTWELL; LEONARD I. LESSER; ROBERT L. PODOSIN

Am J Psychiatry 1972;128:1418-1424.

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Director of Research, Andrew Norman Research Center, Gateways Hospital, 1891 Effie St., Los Angeles, Calif. 90026 and Associate Clinical Professor of Psychiatry, University of California at Los Angeles

Fellow in Child Psychiatry, Neuropsychiatric Institute, University of California at Los Angeles

Director, Child Guidance Center of Orange County, Costa Mesa, Calif., and Associate Clinical Professor of Psychiatry and Pediatrics, University of California at Irvine

Chief, EEG Section, Childrens' Hospital of Los Angeles, Calif.

1972, American Psychiatric Association

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Abstract

The authors conducted a three-week controlled, double-blind (methylphenidate-placebo) study of 31 hyperkinetic boys. Response to treatment was judged on the basis of improvement in pretreatment and posttreatment teacher ratings. Pretreatment measures indicated a high arousal state in those children who obtained a poor clinical response to methylphenidate. Changes in indicators of arousal suggested a greater physiological effect from methylphenidate treatment in the low-arousal (good clinical response) group. The authors' data suggest that genetic factors may play a major role in the etiology of this disorder; however, they stress the need for further research.

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