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The American Journal of Psychiatry, VOL. 128, No. 10

Articles | April 01, 1972

S-adenosylmethionine and Catechol-O-methyltransferase in Schizophrenia

STEVEN MATTHYSSE; ROSS J. BALDESSARINI

Am J Psychiatry 1972;128:1310-1312.

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Assistant Professor of Psychobiology, Psychiatric Research Laboratories, Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, Mass. 02114

Assistant Professor of Psychiatry and Chief of the Neuropsychopharmacology Laboratory, Psychiatric Research Laboratories, Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, Mass. 02114

1972, American Psychiatric Association

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Abstract

The authors examined the hypothesis of disordered transmethylation in schizophrenia by comparing S-adenosylmethionine (SAMe) concentration and cathechol-O-methyltransferase (COMT) activities in venous blood of schizophrenic and nonschizophrenic patients. While they did not find a difference in blood SAMe concentration between the groups, they did find a significant correlation between blood COMT activity and SAMe concentration. This suggests that some schizophrenics may methylate biogenic amines more actively than others.

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