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The American Journal of Psychiatry, VOL. 128, No. 10

Articles | April 01, 1972

Hormonal Potentiation of Imipramine and ECT in Primary Depression

JOHN P. FEIGHNER; LUCY J. KING; MARC A. SCHUCKIT; JACK CROUGHAN; WILLIAM BRISCOE

Am J Psychiatry 1972;128:1230-1238.

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Assistant Clinical Professor, Department of Psychiatry, University of California at San Diego Medcal School, La Jolla, Calif. 92037

Chief Resident, Department of Psychiatry, University of California at San Diego Medcal School, La Jolla, Calif. 92037

U.S. Public Health Service Hospital, Lexington, Ky.

1972, American Psychiatric Association

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Abstract

A double-blind, controlled study with frequent rating of symptoms, using a homogeneous population of 49 patients with primary depression, was conducted to measure the possible enhancement of imipramine's antidepressant activity by T₃ and dexamethasone and the possible enhancement of the antidepressant activity of ECT by dexamethasone. The results of this study, which are clearly negative, raise serious questions as to the efficacy of these hormones in enhancing the antidepressant activity of imipramine and ECT.

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