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The American Journal of Psychiatry, VOL. 128, No. 1

Articles | July 01, 1971

Sodium Intake and Lithium Treatment in Mania

ROBERT G. DEMERS; GEORGE R. HENINGER

Am J Psychiatry 1971;128:100-104.

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Assistant Chief, Department of Psychiatry, Baltimore City Hospitals, 4940 Eastern Ave., Baltimore, Md. 21224, and Instructor in Psychiatry, Johns Hopkins University School of Medicine

Assistant Professor in Psychiatry, Yale University School of Medicine, New Haven, Conn.

1972, American Psychiatric Association

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Abstract

Following an increase in the intake of dietary sodium during treatment with lithium carbonate, the manic symptoms of six patients were observed to increase prior to or coincident with the reduction of side effects. Although sodium intake does influence lithium carbonate treatment, the data suggest that the therapeutic index of lithium carbonate is not improved by increasing dietary sodium.

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