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The American Journal of Psychiatry, VOL. 127, No. 3

Articles | September 01, 1970

A Mechanism of Sudden Death in Chlorpromazine Therapy

ROBERT CANCRO; RUSSELL WILDER

Am J Psychiatry 1970;127:368-371.

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Professor, department of psychiatry, University of Connecticut, 2 Holcomb St., Hartford, Conn. 06112

Menninger Foundation, Topeka, Kans.

1971, American Psychiatric Association

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Abstract

There has been an increasing number of sudden deaths in psychotic patients taking phenothiazines. The authors present a case report that they believe offers some insight into why such deaths occur. They feel that the combination of vasodilatation with the hypotensive effects of phenothiazines might explain some of the unexpected deaths.

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