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The American Journal of Psychiatry, VOL. 127, No. 3

Articles | September 01, 1970

Methysergide as a Treatment for Mania

MICHAEL S. McCABE; THEODORE REICH; GEORGE WINOKUR

Am J Psychiatry 1970;127:354-356.

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Resident, department of psychiatry, Washington University School of Medicine, St. Louis, Mo. 63110

Chief resident, department of psychiatry, Washington University School of Medicine, St. Louis, Mo. 63110

Professor, department of psychiatry, Washington University School of Medicine, St. Louis, Mo. 63110

1971, American Psychiatric Association

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Abstract

Reports of dramatically successful treatment of acute mania with methysergide led the authors to undertake a small study. Twelve patients with acute mania were treated with doses of methysergide that had been reported to be effective. Only one patient recovered; all the others required further therapy. Possible reasons for the failure of methysergide to terminate the manic episode are discussed.

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