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The American Journal of Psychiatry, VOL. 127, No. 3

Articles | September 01, 1970

Placebo-Control Evaluation of Desipramine in Depression

ANTHONY LAPOLLA; HARRY JONES

Am J Psychiatry 1970;127:335-338.

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Assistant superintendent, Camarillo State Hospital, Camarillo, Calif. 93010

Senior psychiatrist in the adolescent treatment center, Camarillo State Hospital, Camarillo, Calif. 93010

1971, American Psychiatric Association

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Abstract

A double-blind clinical trial was conducted to compare the effectiveness of desipramine and placebo in newly hospitalized patients. Analysis of data from 74 patients (34 on desipramine, 40 on placebo) showed that in patients with endogenous depression, the response to desipramine was superior to response to placebo as early as the fifth day of treatment; in patients with neurotic (reactive) depression, no significant differences in response were found.

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