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The American Journal of Psychiatry, VOL. 127, No. 10

Articles | April 01, 1971

Lithium Carbonate and Isocarboxazid—An Effective Drug Approach in Severe Depressions

HARRY ZALL

Am J Psychiatry 1971;127:1400-1403.

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Lieutenant commander in the U.S. Navy, serving as Staff Psychiatrist, Philadelphia Naval Hospital, 17th and Pattison Ave., Philadelphia, Pa. 19145

1971, American Psychiatric Association

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Abstract

The author presents three case reports that emphasize the difficulties in finding an effective antidepressant drug program for regularly recurring depressions. All three patients responded well to the combination of lithium carbonate and isocarboxazid. The author concludes that lithium and at least one monoamine oxidase inhibitor may act synergistically in relieving certain severe depressions in manic-depressive illness.

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