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The American Journal of Psychiatry, VOL. 127, No. 8

Articles | February 01, 1971

Bipolar Depression—A Comparative Study of Patient Characteristics

H. KEITH H. BRODIE; MELITTA J. LEFF

Am J Psychiatry 1971;127:1086-1090.

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Assistant Professor, Department of Psychiatry, Stanford University School of Medicine, Stanford, Calif.

1971, American Psychiatric Association

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Abstract

The authors report their comparison of socioenvironmental, familial, and genetic characteristics in matched groups of bipolar (manic-depressive) and unipolar patients. While affective illness was present in a majority of the families of both groups, bipolar illness appeared only in the families of bipolar patients, suggesting a familial or genetic source for this disease. Parental deprivation and marital failure rates were significantly higher in the bipolar group.

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