Advanced Search

The American Journal of Psychiatry, VOL. 127, No. 8

Articles | February 01, 1971

Changes in Norepinephrine Turnover in Rat Brain During Chronic Administration of Imipramine and Protriptyline: A Possible Explanation for the Delay in Onset of Clinical Antidepressant Effects

JOSEPH J. SCHILDKRAUT; ANDREW WINOKUR; PAUL. R. DRASKÓCZY; JANET H. HENSLE

Am J Psychiatry 1971;127:1032-1039.

View Article Information

Director and Associate Professor of Psychiatry, Neuropsychopharmacology Laboratory, Massachusetts Mental Health Center, Harvard Medical School, Boston, Mass.

Medical student at Tufts University School of Medicine, Boston, Mass.

Pharmacologist and Lecturer on Pharmacology, Neuropsychopharmacology Laboratory, Massachusetts Mental Health Center, Harvard Medical School, Boston, Mass.

Member of the staff, Neuropsychopharmacology Laboratory, Massachusetts Mental Health Center, Harvard Medical School, Boston, Mass.

1971, American Psychiatric Association

Article

text A A A

PDF of the full text article.

Abstract

In this study the authors compare the effects of acute and chronic administration of the tricyclic antidepressants imipramine and protriptyline on the turnover and matabolism of norepinephrine in rat brain. The turnover of norepinephrine was decreased after acute administration but increased during chronic administration of these drugs. This increase in norepinephrine turnover occurred sooner when thyroxine was administered with the imipramine. This may help to explain why clinical antidepressant effects are generally observed only after chronic administration of imipramine or protriptyline and why thyroid hormone may accelerate and enhance the clinical antidepressant effects of imipramine.

Figures in this Article

Your Session has timed out. Please sign back in to continue.

Username

Password

Sign in via Athens (What is this?)

Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.

Forgot Password?

Not a subscriber?

Subscribe Now/Learn More

Purchase Online access to this article for 24 hours

PsychiatryOnline subscription options offer access to the DSM-IV-TR® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.

Submit a Comments

Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of JBJS editorial staff.

* = Required Field

Comment Author(s)*(if multiple authors, separate names by comma)

Example: John Doe

Affiliation & Institution*

Comment Title*

Comment*

Cancel

Topics

Product Recommendation

CME Activity