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A Theory of Neuronal Malfunction in Schizophrenia
JACQUES S. GOTTLIEB; CHARLES E. FROHMAN; PETER G. S. BECKETT
Am J Psychiatry 1969;126:149-156.
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Director, Lafayette Clinic, 951 E. Lafayette, Detroit, Mich. 48207, professor and chairman, department of psychiatry, Wayne State University
Associate director, head, biochemistry laboratories, Lafayette Clinic, 951 E. Lafayette, Detroit, Mich. 48207, assistant professor, department of biochemistry, Wayne State University
Lafayette Clinic, 951 E. Lafayette, Detroit, Mich. 48207, professor, department of psychiatry, Wayne State University
1970, American Psychiatric Association
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Abstract
A considerable amount of biological research into schizophrenia, mainly upon blood fluids, is performed throughout the world. The authors report their latest findings on a plasma protein factor and relate these findings to other domestic research and to recent research in other nations, particularly the Soviet Union. They hypothesize that a malcontrolled blood protein contributes to the genesis of schizophrenia by selectively altering neuronal permeability to precursors of important neurotransmitters; if this occurs, it would disrupt information processing in the brain.Abstract Teaser
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