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The American Journal of Psychiatry, VOL. 125, No. 4

Articles | October 01, 1968

The Use of Lithium in Affective Disorders: II. Prophylaxis of Depression in Chronic Recurrent Affective Disorder

RONALD R. FIEVE; STANLEY H. PLATMAN; ROBERT R. PLUTCHIK

Am J Psychiatry 1968;125:492-498.

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Chief of psychiatric research, internal medicine, New York State Psychiatric Institute, 722 West 168th St., New York, N. Y. 10032, assistant professor of clinical psychiatry, Columbia University College of Physicians and Surgeons

Associate research scientist, department of internal medicine, New York State Psychiatric Institute, 722 West 168th St., New York, N. Y. 10032

1968-69, American Psychiatric Association

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Abstract

In a longitudinal outpatient study, the authors found that lithium produced a mild decrease in depth of depression scores among patients who had been on the drug for more than seven months, as compared with patients who had been receiving lithium less than seven months. They assess the factors contributing to reported positive clinical results of maintenance lithium treatment in recurrent affective disorder.

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