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The American Journal of Psychiatry, VOL. 125, No. 4

Articles | October 01, 1968

The Use of Lithium in Affective Disorders: I. Acute Endogenous Depression

RONALD R. FIEVE; STANLEY R. PLATMAN; ROBERT H. PLUTCHIK

Am J Psychiatry 1968;125:487-491.

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Chief of psychiatric research, internal medicine, New York State Psychiatric Institute, 722 West 168th St., New York, N. Y. 10032, assistant professor of clinical psychiatry, Columbia University College of Physicians and Surgeons

Associate research scientist, department of internal medicine, New York State Psychiatric Institute, 722 West 168th St., New York, N. Y. 10032

1968-69, American Psychiatric Association

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Abstract

A double-blind study involving 29 patients was designed to investigate the efficacy of lithium compared with imipramine in the treatment of acute endogenous depression. After two to three weeks, there was evidence of a moderate to strong antidepressant effect of imipramine, while lithium produced only a weak to mild antidepressant effect. The authors discuss these findings in the light of other reports on the use of lithium in the treatment of acute endogenous depression.

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