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The American Journal of Psychiatry, VOL. 125, No. 12

Articles | June 01, 1969

Possible Interaction Between Disulfiram and Isoniazid

H. G. WHITTINGTON; LESLIE GREY

Am J Psychiatry 1969;125:1725-1729.

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Director of psychiatry, the Department of Health and Hospitals, West Sixth Ave. and Cherokee St., Denver, Colo. 80204

Private practice in Denver

1968-69, American Psychiatric Association

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Abstract

In seven reported cases coordination difficulties and changes in affect and behavior developed following the concurrent administration of isoniazid and disulfiram. The authors suggest the possibility that these compounds, when administered in combination, may significantly alter metabolism of brain catecholamines.

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