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The American Journal of Psychiatry, VOL. 124, No. 5

Articles | November 01, 1967

An Early Clinical Evaluation of Clopenthixol in Treatment-Resistant Female Schizophrenic Patients

ARTHUR WOLPERT; CHARLES SHEPPARD; SIDNEY MERLIS

Am J Psychiatry 1967;124:702-705.

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Research Division, Central Islip State Hospital, Central Islip, N. Y. 11722

1967-68, American Psychiatric Association

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Abstract

Some published results from the European literature regarding the therapeutic and untoward effects of clopenthixol therapy were replicated. Therapeutic response was demonstrated at a daily dosage of 50 mg. An initial drowsiness was noted within a few days of therapy. No laboratory abnormalities were noted.The global impressions of the ward physician were confirmed by the statistical evaluation of the rating data. A significant improvement was demonstrated in this sample of treatment-resistant, chronic female schizophrenics. This has encouraged us to formulate a further, more extensive investigation of clopenthixol in a larger double-blind comparative study.

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