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The American Journal of Psychiatry, VOL. 124, No. 11

Articles | May 01, 1968

Clinical Studies of Cyclazocine in the Treatment of Narcotic Addiction

ALFRED M. FREEDMAN; MAX FINK; ROBERT SHAROFF; ARTHUR ZAKS

Am J Psychiatry 1968;124:1499-1504.

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Professor and chairman, Department of psychiatry, New York Medical College—Metropolitan Hospital Medical Center, 5 East 102nd Street, New York, N. Y. 10029

Professor, Department of psychiatry, New York Medical College—Metropolitan Hospital Medical Center, 5 East 102nd Street, New York, N. Y. 10029

Associative Professor, Department of psychiatry, New York Medical College—Metropolitan Hospital Medical Center, 5 East 102nd Street, New York, N. Y. 10029

Psychiatric resident, Department of psychiatry, New York Medical College—Metropolitan Hospital Medical Center, 5 East 102nd Street, New York, N. Y. 10029

1967-68, American Psychiatric Association

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Abstract

Cyclazocine, a long-acting narcotic antagonist, was found to be safe and useful in the treatment of narcotic addicts in a voluntary municipal hospital. Treatment induction in 15 days to a daily maintenance dose of 4.0 mg. was well tolerated. That dosage effectively blocked clinical and EEG effects of challenges with 15 mg. of intravenous heroin, administered in two minutes, for periods greater than 24 hours. Cyclazocine treatment permits "engagement" and continuity of rehabilitation and resocialization efforts, and provides a useful alternative to the methadone maintenance treatment model.

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