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The American Journal of Psychiatry, VOL. 124, No. 10

Articles | April 01, 1968

Drugs and Dreams III: The Effects of Imipramine on the Dreams of Depressed Patients

MILTON KRAMER; ROY M. WHITMAN; BILL BALDRIDGE; PAUL H. ORNSTEIN

Am J Psychiatry 1968;124:1385-1392.

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Assistant Professor, Department of psychiatry, University of Cincinnati College of Medicine, assistant professor in psychology, Veterans Administration Hospital, 3200 Vine Street, Cincinnati, Ohio 45220, assistant chief, psychiatric service

Professor, Department of psychiatry, University of Cincinnati College of Medicine, professor in psychology, psychiatric consultant

Department of psychiatry, University of Cincinnati College of Medicine, instructor in psychology, Veterans Administration Hospital, 3200 Vine Street, Cincinnati, Ohio 45220, consulting psychologist

Associate Professor, Department of psychiatry, University of Cincinnati College of Medicine, associate professor in psychology

1967-68, American Psychiatric Association

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Abstract

An examination of the dreams of depressed patients revealed that there are measurable changes in dream content which accompany imipramine treatment and clinical improvement. The findings are consistent with a view of the intrapsychic condition in depression as being high in feelings of hostility and anxiety and low in heterosexuality and motility. The essential psychopharmacologic action of imipramine in depression is a two-step effect in which hostility is mobilized and then discharged.

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