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The American Journal of Psychiatry, VOL. 124, No. 9

Articles | March 01, 1968

The Metabolism of Dimethoxyphenethylamine, A Compound Found in the Urine of Schizophrenics

JACK W. SCHWEITZER; ARNOLD J. FRIEDHOFF

Am J Psychiatry 1968;124:1249-1253.

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Instructor in experimental psychiatry, center for study of psychotic disorders, department of psychiatry and neurology, New York University School of Medicine

Professor of psychiatry, center for study of psychotic disorders, department of psychiatry and neurology, New York University School of Medicine

1967-68, American Psychiatric Association

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Abstract

DMPEA was injected into test rats to determine the pathways of its metabolism and to identify the resultant metabolites and their effects. The substance was absorbed into the liver, spleen, lungs, heart, and brain (minute amounts), and the course of its metabolism and the behavior of its metabolites were followed successfully. By administering the substance and its metabolites to test groups of schizophrenics and normal subjects, it may be possible to determine whether any block in the metabolism of this substance exists in schizophrenic patients.

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