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The American Journal of Psychiatry, VOL. 123, No. 8

Articles | February 01, 1967

Cerebrospinal Fluid Glycoproteins in Schizophrenia

ROBERT J. CAMPBELL; SAMUEL BOGOCH; MICHAEL J. SCOLARO; PETER C. BELVAL

Am J Psychiatry 1967;123:952-962.

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Director of the Psychiatric Research Program, St. Vincent's Hospital and Medical Center of New York, 153 West 11th Street, New York, N. Y. 10011

St. Vincent's, Hospital and Medical Center of New York, 153 West 11th Street, New York, N. Y. 10011

Director, Foundation for Research on the Nervous System, Boston, Mass.

Foundation for Research on the Nervous System, Boston, Mass.

1966-67, American Psychiatric Association

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Abstract

A double-blind clinical and chemical study of 131 hospitalized psychotic patients, totally removed geographically from the center at which chemical analyses were performed, demonstrated an inverse relationship between the quantity of cerebrospinal fluid glycoprotein neuraminic acid and the severity of schizophrenia, with a high concordance between chemical levels, changes in clinical condition, and family history. In addition, changes in cerebrospinal fluid glycoprotein hexose were related inversely to clinical estimates of depression.

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