Data on a group of 414 patients who underwent multiple lobotomies and were followed over an average period of 12.4 years from the first operation confirm the belief that such operations are worthwhile in patients who relapse after the first lobotomy The orbitomedial quadrants are the most promising site of operation in patients with affective, psychoneurotic, and early schizophrenic disorders, while an additional incision into the frontotemporal connections benefits those who are disturbed by hallucinations.Abstract Teaser