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The American Journal of Psychiatry, VOL. 120, No. 6

CLINICAL NOTES | December 01, 1963

THORAZINE AS AN EPILEPTOGENIC AGENT

WILLIAM S. MCCABE; JOSEPH A. HABOVICK

Am J Psychiatry 1963;120:595-597.

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Staff Psychiatrist, Woodville State Hospital, Woodville, Pa.

Staff Nurse, Woodville State Hospital, Woodville, Pa.

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Abstract

Thorazine is not an epileptogenic agent, instead it acts synergistically with Dilantin and Mysoline to reduce both the number and severity of grand mal seizures. An incidental finding was that Dilantin significantly alters the behavior of a number of schizophrenics when added to their daily medication indicating a stimulation of schizophrenic-like behavior in a certain number of sub-threshold (sub-clinical) convulsive individuals.

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