Nineteen hospitalized, chronic female schizophrenics were treated with combined amitriptyline-perphenezine for a period of 12 weeks.Patients were evaluated initially and during the study in terms of standard rating scales, ward behavior, and global clinical judgment.Observations and test data indicate that the patients as a group showed improvement, and the combination of amitriptyline- perphenezine seems compatible. However, since this pilot study did not include a placebo control, no definite conclusion can be drawn at this time. The results are sufficiently encouraging to warrant controlled clinical trial.Abstract Teaser