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The American Journal of Psychiatry, VOL. 120, No. 1

Article | July 01, 1963

A COMPREHENSIVE METHOD FOR THE DETERMINATION OF URINARY CHLORPROMAZINE AND ITS OXIDATIVE METABOLITES

IRENE S. FORREST; MAGDALENA BERGER WECHSLER; JOSEPH E. SPERCO

Am J Psychiatry 1963;120:44-48.

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Biochem. Research Lab., VA Hospital, Palo, Calif., Dept. Exp. Psychiatry, N. Y. State Psychiatric Institute, Food and Drug Administration, Boston, Mass.

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Abstract

1. A method for the determination of urinary chlorpromazine and its metabolites employing adsorption on Dowex 50 W-X4 cation exchange resin is described.2. Polar, intermediary oxidative and conjugated metabolites constitute by far the largest drug fraction, amounting to approximately 80% of total urinary drug.3. One half of administered daily drug doses was found to be excreted in the urine.4. Recoveries by this method range from 88% to 97%.

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