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The American Journal of Psychiatry, VOL. 119, No. 5

Article | November 01, 1962

IMIPRAMINE IN DEPRESSION : A CONTROLLED STUDY

NORMAN ROULET; ROBERT R. ALVAREZ; J. PATRICK DUFFY; L. DOUGLAS LENKOSKI; T. GEORGE BIDDER

Am J Psychiatry 1962;119:427-431.

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University Hospitals of Cleveland and the Dept. of Psychiatry, Western Reserve University School of Medicine.

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Abstract

The antidepressant drug imipramine was evaluated by means of a double blind study. Therapeutic results were assessed on the basis of a rating scale, psychological tests, and clinical course. Differences favoring the drug were found in some of the psychological tests, but in no clinical area were there significant differences between drug and placebo.

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