Nine severely deteriorated chronic schizophrenic patients were treated continuously for 115 days with carphenazine in daily doses that were initiated at 25 mg. and ultimately raised to 100, 150, 200 and 300 mg. Three showed moderate and 5 slight overall reduction in symptoms.The findings in bi-weekly transaminase determinations and weekly complete blood counts and urinalyses remained within normal limits for all patients throughout treatment. According to these preliminary data, carphenazine appears to be a safe agent for long term antipsychotic treatment.Abstract Teaser