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The American Journal of Psychiatry, VOL. 118, No. 4

CLINICAL NOTES | October 01, 1961

BEHAVIORAL EVALUATION OF IMIPRAMINE AND NIALAMIDE IN REGRESSED SCHIZOPHRENIC PATIENTS WITH DEPRESSIVE FEATURES

CARL A. LEUTHOLD; F. J. BRADSHAW; G. W. ARNDT; E. F. HOFFMAN; VLADIMIR PISHKIN

Am J Psychiatry 1961;118:354-355.

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Chief, Psychology Service; Veterans Administration Hospital, Tomah, Wisconsin.

Director, Professional Services; Veterans Administration Hospital, Tomah, Wisconsin.

Staff Psychiatrist; Veterans Administration Hospital, Tomah, Wisconsin.

Staff Physician; Veterans Administration Hospital, Tomah, Wisconsin.

Director, Research Laboratory, Veterans Administration Hospital, Tomah, Wisconsin.

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Abstract

Imipramine and nialamide were found to be comparable as measured by psychiatrist's clinical ratings of over-all improvement in patients with depressive symptoms. On measures of specffic behavioral factors on the MACC scale the two drug groups were differentiated by improved motility in patients on imipramine and by positive changes in affect in patients receiving nialamide during the first 6 weeks of drug administration.

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