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The American Journal of Psychiatry, VOL. 118, No. 4

CLINICAL NOTES | October 01, 1961

RECURRENT THIOPERAZINE-INDUCED EXTRAPYRAMIDAL REACTION FOLLOWING PLACEBO SUBSTITUTION FOR MAINTENANCE ANTIPARKINSON DRUG

WILLIAM MANDEL; BESSIE CLAFFEY; LESTER H. MARGOLIS

Am J Psychiatry 1961;118:351-352.

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Chief of Research, Napa State Hospital, Imola, Calif.

Staff Psychiatrist, Napa State Hospital, Imola, Calif.

Consultant, Napa State Hospital, Imola, Calif.

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Abstract

A placebo was abruptly substituted for maintenance antiparkinson drug in 20 patients who had previously shown evidence of a thioperazine-induced extrapyramidal reaction. Within 20 days of this controlled study extrapyramidal reactions reappeared in 16 patients (80%). The recurrence rate of phenothiazine-induced extrapyramidal reactions following withdrawal of maintenance antiparkinson drug will vary with different situations and their incidence can only be determined by clinical trial.

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