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The American Journal of Psychiatry, VOL. 117, No. 10
CLINICAL NOTES   |   April 01, 1961 
THRESHOLDS FOR DRUG-INDUCED AKATHISIA
DANIEL X. FREEDMAN; JACOB DE JONG
Am J Psychiatry 1961;117:930-931.
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Assistant Professor of Psychiatry, Psychopharmacology Laboratory, Departments of Psychiatry and Pharmacology, School of Medicine, Yale University, New Haven, Conn.
Physician and Psychiatrist, Fairfield State Hospital, Newtown, Conn.
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Abstract
The findings indicate that low-dose akathisia results from an individual's specific sensitivity to a specific molecular configuration. There is a population with a low threshold for the disorder. Thresholds are determined by the spectrum of individual sensitivities for specific molecular configurations, administered in a specified dosage schedule. The incidence and intensity of low-dose akathisia depend on at least 2 factors: the population tested, and specific molecular structure. [SEE TABLE 1 IN SOURCE PDF]Abstract Teaser
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