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The American Journal of Psychiatry, VOL. 117, No. 5

CLINICAL NOTES | November 01, 1960

THE USE OF FLUPHENAZINE (PROLIXIN) IN REHABILITATION OF CHRONIC SCHZOPHRENIC PATIENTS

LEON REZNIKOFF

Am J Psychiatry 1960;117:457-458.

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Clinical Director, Hudson County Hospital for Mental Diseases, Secaucus, N. J.

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Abstract

1. Fifty chronic schizophrenic patients with an average duration of mental illness of over 12 years and refractory to any other treatment had been treated with fluphenazine for a period of 3 to 4 months.2. Twenty-nine patients (58%) improved and 21 (42%) remained unimproved.3. The dose of fluphenazine varied from 2.5 mg. to 20 mg. per day. When the dose of fluphenazine was raised over 10 mg. per day, 50% of patients developed extrapyramidal symptoms.4. Fluphenazine is a valuable adjunct in the total program of rehabilitation of chronic schizophrenic patients.

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