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The American Journal of Psychiatry, VOL. 117, No. 11

CLINICAL NOTES | May 01, 1961

COMBINED TRANYLCYPROMINE-TRIFLUOPERAZINE THERAPY IN THE TREATMENT OF PATIENTS WITH AGITATED DEPRESSIONS

STANLEY LESSE

Am J Psychiatry 1961;117:1038-1039.

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The Neurological Institute of the Presbyterian Hospital of New York and the Department of Neurology, Columbia University.

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Abstract

The tranylcypromine-trifluoperazine combination is of definite benefit in the treatment of patients with severe agitated depressions. In the author's experience this combination represents the only psychopharmacologic antidepressant that is of proven worth in this particular very prevalent clinical group. While others have reported that this combination has been of benefit in the treatment of chronic, regressed and withdrawn patients(4) and in chronic refractory schizophrenics(5), I have not found this to be true. To the contrary, this combination is of benefit primarily in patients with a marked increase in psychomotor activity.

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